The degradation mechanisms of solution processed small molecule phosphorescent OLEDs are investigated along with thermal evaporated devices. Hole-induced degradation in the presence of excited states is found to be a major culprit for the fast degradation in solution-processed devices. Frontiers Targeted Protein Degradation by Chimeric Small
- Modalities of Recent Drug DevelopmentClassification of Degrader MoleculesDevelopment of Chimeric Degrader MoleculesFeatures of The Chimeric Degrader MoleculesChimeric Degrader Molecules as Probes to Understand The Ubiquitin CodeConclusionFundingConflict of InterestSmall molecule probes for targeting autophagy Nature May 25, 2021 · Autophagy is an essential catabolic cellular degradation process. It is responsible for the degradation of damaged or otherwise dispensable proteins, as well as aggregates 1 and droplets 2, by
The therapeutic modality of targeted protein degradation promises to overcome limitations of traditional pharmacology. Small-molecule degraders recruit disease-causing proteins to E3 ubiquitin ligases, prompt-ing their ubiquitination and degradation by the proteasome. The Small-molecule-induced polymerization triggers degradation Nov 18, 2020 · Here we report an alternative mechanism of targeted protein degradation, in which a small molecule induces the highly specific, reversible polymerization of a target protein, followed by its sequestration into cellular foci and subsequent degradation. BI-3802 is a small molecule that binds to the Broad-complex, Tramtrack and Bric-à-brac (BTB) domain of the oncogenic transcription factor B cell lymphoma 6 (BCL6) and leads to the proteasomal degradation TRIP12 promotes small-molecule-induced degradation Targeted protein degradation is an emerging therapeutic paradigm. Kaiho-Soma et al. found that the K29-linkage specific ubiquitin ligase TRIP12 promotes small-molecule-induced and CRL2-mediated degradation of neo-substrates such as BRD4. They identified K29/K48-branched ubiquitin chains as a ubiquitin code used for chemically induced targeted protein degradation.
Jun 20, 2021 · proaches to small-molecule screens have been employed for the identication of novel chemical inhibitors . Another promising strategy exploiting the UPS is targeted protein degradation, such as the proteolysis-targeting chimera (PROTAC) technology . PRO-TAC therapeutics can utilize small-molecule warheads to hijack UPS machinery and meCLICK-Seq, a Substrate-Hijacking and RNA limits their applicability. Small molecules that target and degrade RNA circumvent many of these limitations and expand the scope for RNA degradation approaches.7,8 So far, their availability is limited and their platforms lack the modularity of genetically encoded approaches. Thus, a strategy that retains the modularity and scope of small-moleculeDegradation mechanisms of small-molecule :fullerene Jul 14, 2015 · Degradation mechanisms of small-molecule :fullerene blends. admin. July 14, 2015. Organic Solar Cells. Although phthalocyanines and C60 are employed in various applications, their stability in photovoltaic devices has been less investigated than solution-processed organic semiconductors. We outline in this part the major differences and